Sisters Sisters is an Emmy Award-winning television drama. It follows the lives and loves of four close, but very different, sisters of the Reed family living in Winnetka, Illinois. Details Casts Galleries Posters Season Lists Title Sisters Genres Drama Comedy First Air Date 1991-05-11 Last Air Date 1996-05-04 Episode Runtime 01 Hours 00 Minutes Total Season(s) 6 Total Episode(s) on All Seasons 127 Runtime 60 Production Companies Warner Bros. Television, Cowlip Productions, Lorimar Television Swoosie Kurtz... Alex Reed... Sela Ward... Teddy Reed... Patricia Kalember... Georgie Reed... Sheila Kelley... Charley Bennett... Elizabeth Hoffman... Beatrice Reed... Heather McAdam... Catherine Margolis... Original Size (1280x720) Original Size (3840x2160) Original Size (1280x720) Original Size (3840x2160) Original Size (2000x3000) Original Size (960x1440) Original Size (1000x1500) Season 1 7 Episode(s) 1991-05-11 Season 2 22 Episode(s) 1991-09-21 Season 3 24 Episode(s) 1992-09-26 Season 4 22 Episode(s) 1993-09-25 Season 5 24 Episode(s) 1994-09-24 Season 6 28 Episode(s) 1995-09-23